Antidiabetic drugs are medications used to treat diabetes mellitus by lowering blood glucose levels. With the exception of insulin, exenatide, liraglutide and pramlintide, all are administered orally and are thus also called oral hypoglycemic agents. This pharmacology lecture covers topics such as pathophysiology of diabetes mellitus type 1 & type 2, hyperglycemia, hypoglycemia, insulin production, pancreatic beta & alpha cells, glycogen, glucagon, glucose function; mechanism of action of glucose-lowering drugs; rapid, short, intermediate, long -acting insulin analogs, synthetic amylin, incretin mimetics, DPP-4 inhibitors, sulfonylureas, glinides, biguanides, thiazolidinediones, sodium-glucose cotransporter-2 inhibitors, and alpha-glucosidase inhibitors. Drugs mentioned include insulins Lispro, Aspart, Glulisine, Regular, NPH (isophane), Detemir, Glargine, Degludec; Pramlintide; Exenatide, Liraglutide; Alogliptin, Linagliptin, Saxagliptin, Sitagliptin; Glimepiride, Glyburide, Glipizide; Nateglinide, Repaglinide; Metformin; Pioglitazone, Rosiglitazone; Canagliflozin, Dapagliflozin; Acarbose, and Miglitol.

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28 thoughts on “Pharmacology – DRUGS FOR DIABETES (MADE EASY)

  1. Correction at 10:34; rising levels of ATP inhibit ATP-sensitive Potassium Channel and thus block the OUTFLOW of potassium

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    Hypoglycemia is a clinical state with low glucose concentration in the blood, usually associated with giddiness, weakness, anxiety, irritability, hunger, palpitation, blurred vision, headache, inability to concentrate, loss of memory, and in severe cases, paralysis, seizures or coma. Patients with diabetes start getting symptoms of hypoglycemia when the sugar levels drop below 70 mg/dl but this can vary widely from person to person. Hypoglycemia usually occurs when a meal is missed or delayed, following unaccustomed heavy exercise or when too high a dose of insulin or diabetes tablets is taken in error.
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